Biomarkers of Inflammation and Coagulation Are Associated With Mortality and Hepatitis Flares in Persons Coinfected With HIV and Hepatitis Viruses
Identifieur interne : 005072 ( Main/Exploration ); précédent : 005071; suivant : 005073Biomarkers of Inflammation and Coagulation Are Associated With Mortality and Hepatitis Flares in Persons Coinfected With HIV and Hepatitis Viruses
Auteurs : Bruno Bezerril Andrade [France] ; Katherine Huppler Hullsiek [États-Unis] ; David R. Boulware [États-Unis] ; Adam Rupert [États-Unis] ; Martyn A. French [Australie] ; Kiat Ruxrungtham [Thaïlande] ; Marisa Luisa Montes [Espagne] ; Huw Price [Royaume-Uni] ; Pablo Barreiro [Espagne] ; Jennifer Audsley [Australie] ; Alan Sher [France] ; Sharon R. Lewin [Australie] ; Irini Sereti [France]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
Abstract
Background. Hepatitis C virus (HCV) and/or hepatitis B virus (HBV) coinfection with human immunodeficiency virus (HIV) has a greater risk of mortality than either HCV or HBV infection alone and is frequently associated with hepatitis flares after antiretroviral therapy (ART) initiation. Methods. We performed a retrospective cohort study of 287 HIV-positive persons coinfected with HBV and/ or HCV (70 had HBV coinfection only, 207 had HCV coninfection only, and 10 had HBV and HCV coinfections) who had pre-ART plasma samples evaluated for biomarkers associated with death (within 4 years) and/or hepatitis flare (within 4 months) after ART initiation. A predictive biomarker risk score was calculated. Results. Forty-eight deaths and 50 hepatitis flares occurred. Nonsurvivors were older, had more prior AIDS-defining events, and had higher pre-ART triglycerides and aspartate transaminase levels. Detectable hyaluronic acid and higher D-dimer, interleukin 6, interleukin 8, and soluble CD14 levels were associated with death in uni-variate models and with a composite biomarker risk score. The risk of hepatitis flares was higher with HBV coinfection only (24.3%) and with HBV and HCV coinfection (50%) than with HCV coinfection only (13.5%). Higher levels of alanine transaminase and interleukin 10 were also associated with hepatitis flares. Conclusions. Among HIV-positive patients coinfected with HBV and/or HCV who are initiating ART, biomarkers of inflammation and coagulation are associated with an increased risk of death, whereas HBV coinfection and higher pre-ART interleukin 10 levels are associated with hepatitis flares.
Affiliations:
- Australie, Espagne, France, Royaume-Uni, Thaïlande, États-Unis
- Angleterre, Communauté de Madrid, Grand Londres, Maryland, Victoria (État)
- Londres, Madrid, Melbourne
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Lewin</name><affiliation><inist:fA14 i1="11"><s1>The Alfred Hospital</s1><s3>INC</s3><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><wicri:noCountry>INC</wicri:noCountry></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Monash University</s1><s3>AUS</s3><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Monash University</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Burnet Institute</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Sereti, Irini" sort="Sereti, Irini" uniqKey="Sereti I" first="Irini" last="Sereti">Irini Sereti</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy Infectious Diseases, National Institutes of Health</s1><s2>Bethesda</s2><s3>FRA</s3><sZ>13 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Bethesda</wicri:noRegion><wicri:noRegion>National Institutes of Health</wicri:noRegion><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0155987</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0155987 INIST</idno><idno type="RBID">Pascal:13-0155987</idno><idno type="wicri:Area/PascalFrancis/Corpus">000B14</idno><idno type="wicri:Area/PascalFrancis/Curation">005354</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000A82</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000A82</idno><idno type="wicri:doubleKey">0022-1899:2013:Bezerril Andrade B:biomarkers:of:inflammation</idno><idno type="wicri:Area/Main/Merge">005256</idno><idno type="wicri:Area/Main/Curation">005072</idno><idno type="wicri:Area/Main/Exploration">005072</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Biomarkers of Inflammation and Coagulation Are Associated With Mortality and Hepatitis Flares in Persons Coinfected With HIV and Hepatitis Viruses</title><author><name sortKey="Bezerril Andrade, Bruno" sort="Bezerril Andrade, Bruno" uniqKey="Bezerril Andrade B" first="Bruno" last="Bezerril Andrade">Bruno Bezerril Andrade</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health</s1><s2>Bethesda</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Bethesda</wicri:noRegion><wicri:noRegion>National Institutes of Health</wicri:noRegion><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Huppler Hullsiek, Katherine" sort="Huppler Hullsiek, Katherine" uniqKey="Huppler Hullsiek K" first="Katherine" last="Huppler Hullsiek">Katherine Huppler Hullsiek</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>University of Minnesota</s1><s2>Minneapolis</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>University of Minnesota</wicri:noRegion></affiliation></author><author><name sortKey="Boulware, David R" sort="Boulware, David R" uniqKey="Boulware D" first="David R." last="Boulware">David R. Boulware</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>University of Minnesota</s1><s2>Minneapolis</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>University of Minnesota</wicri:noRegion></affiliation></author><author><name sortKey="Rupert, Adam" sort="Rupert, Adam" uniqKey="Rupert A" first="Adam" last="Rupert">Adam Rupert</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>SAIC Frederick, National Cancer Institute</s1><s2>Frederick, Maryland</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="French, Martyn A" sort="French, Martyn A" uniqKey="French M" first="Martyn A." last="French">Martyn A. French</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>University of Western Australia</s1><s2>Perth</s2><s3>AUS</s3><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>University of Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Ruxrungtham, Kiat" sort="Ruxrungtham, Kiat" uniqKey="Ruxrungtham K" first="Kiat" last="Ruxrungtham">Kiat Ruxrungtham</name><affiliation><inist:fA14 i1="05"><s1>Faculty of Medicine, Chulalongkorn University</s1><s3>INC</s3><sZ>6 aut.</sZ></inist:fA14><wicri:noCountry>INC</wicri:noCountry></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>HIV-NAT, Thai Red Cross AIDS Research Center</s1><s2>Bangkok</s2><s3>THA</s3><sZ>6 aut.</sZ></inist:fA14><country>Thaïlande</country><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Montes, Marisa Luisa" sort="Montes, Marisa Luisa" uniqKey="Montes M" first="Marisa Luisa" last="Montes">Marisa Luisa Montes</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Hospital La Paz</s1><s3>ESP</s3><sZ>7 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Hospital La Paz</wicri:noRegion></affiliation></author><author><name sortKey="Price, Huw" sort="Price, Huw" uniqKey="Price H" first="Huw" last="Price">Huw Price</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>MRC Clinical Trials Unit</s1><s2>London</s2><s3>GBR</s3><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Barreiro, Pablo" sort="Barreiro, Pablo" uniqKey="Barreiro P" first="Pablo" last="Barreiro">Pablo Barreiro</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Hospital Carlos III</s1><s2>Madrid</s2><s3>ESP</s3><sZ>9 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Audsley, Jennifer" sort="Audsley, Jennifer" uniqKey="Audsley J" first="Jennifer" last="Audsley">Jennifer Audsley</name><affiliation><inist:fA14 i1="11"><s1>The Alfred Hospital</s1><s3>INC</s3><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><wicri:noCountry>INC</wicri:noCountry></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Monash University</s1><s3>AUS</s3><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Monash University</wicri:noRegion></affiliation></author><author><name sortKey="Sher, Alan" sort="Sher, Alan" uniqKey="Sher A" first="Alan" last="Sher">Alan Sher</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health</s1><s2>Bethesda</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Bethesda</wicri:noRegion><wicri:noRegion>National Institutes of Health</wicri:noRegion><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Lewin, Sharon R" sort="Lewin, Sharon R" uniqKey="Lewin S" first="Sharon R." last="Lewin">Sharon R. Lewin</name><affiliation><inist:fA14 i1="11"><s1>The Alfred Hospital</s1><s3>INC</s3><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><wicri:noCountry>INC</wicri:noCountry></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Monash University</s1><s3>AUS</s3><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Monash University</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Burnet Institute</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Sereti, Irini" sort="Sereti, Irini" uniqKey="Sereti I" first="Irini" last="Sereti">Irini Sereti</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy Infectious Diseases, National Institutes of Health</s1><s2>Bethesda</s2><s3>FRA</s3><sZ>13 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Bethesda</wicri:noRegion><wicri:noRegion>National Institutes of Health</wicri:noRegion><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological marker</term><term>Hepatitis</term><term>Human</term><term>Human immunodeficiency virus</term><term>Infection</term><term>Inflammation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Homme</term><term>Virus immunodéficience humaine</term><term>Marqueur biologique</term><term>Inflammation</term><term>Infection</term><term>Hépatite</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Hepatitis C virus (HCV) and/or hepatitis B virus (HBV) coinfection with human immunodeficiency virus (HIV) has a greater risk of mortality than either HCV or HBV infection alone and is frequently associated with hepatitis flares after antiretroviral therapy (ART) initiation. Methods. We performed a retrospective cohort study of 287 HIV-positive persons coinfected with HBV and/ or HCV (70 had HBV coinfection only, 207 had HCV coninfection only, and 10 had HBV and HCV coinfections) who had pre-ART plasma samples evaluated for biomarkers associated with death (within 4 years) and/or hepatitis flare (within 4 months) after ART initiation. A predictive biomarker risk score was calculated. Results. Forty-eight deaths and 50 hepatitis flares occurred. Nonsurvivors were older, had more prior AIDS-defining events, and had higher pre-ART triglycerides and aspartate transaminase levels. Detectable hyaluronic acid and higher <sub>D</sub>-dimer, interleukin 6, interleukin 8, and soluble CD14 levels were associated with death in uni-variate models and with a composite biomarker risk score. The risk of hepatitis flares was higher with HBV coinfection only (24.3%) and with HBV and HCV coinfection (50%) than with HCV coinfection only (13.5%). Higher levels of alanine transaminase and interleukin 10 were also associated with hepatitis flares. Conclusions. Among HIV-positive patients coinfected with HBV and/or HCV who are initiating ART, biomarkers of inflammation and coagulation are associated with an increased risk of death, whereas HBV coinfection and higher pre-ART interleukin 10 levels are associated with hepatitis flares.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Espagne</li><li>France</li><li>Royaume-Uni</li><li>Thaïlande</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Communauté de Madrid</li><li>Grand Londres</li><li>Maryland</li><li>Victoria (État)</li></region><settlement><li>Londres</li><li>Madrid</li><li>Melbourne</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Bezerril Andrade, Bruno" sort="Bezerril Andrade, Bruno" uniqKey="Bezerril Andrade B" first="Bruno" last="Bezerril Andrade">Bruno Bezerril Andrade</name></noRegion><name sortKey="Sereti, Irini" sort="Sereti, Irini" uniqKey="Sereti I" first="Irini" last="Sereti">Irini Sereti</name><name sortKey="Sher, Alan" sort="Sher, Alan" uniqKey="Sher A" first="Alan" last="Sher">Alan Sher</name></country><country name="États-Unis"><noRegion><name sortKey="Huppler Hullsiek, Katherine" sort="Huppler Hullsiek, Katherine" uniqKey="Huppler Hullsiek K" first="Katherine" last="Huppler Hullsiek">Katherine Huppler Hullsiek</name></noRegion><name sortKey="Boulware, David R" sort="Boulware, David R" uniqKey="Boulware D" first="David R." last="Boulware">David R. Boulware</name><name sortKey="Rupert, Adam" sort="Rupert, Adam" uniqKey="Rupert A" first="Adam" last="Rupert">Adam Rupert</name></country><country name="Australie"><noRegion><name sortKey="French, Martyn A" sort="French, Martyn A" uniqKey="French M" first="Martyn A." last="French">Martyn A. French</name></noRegion><name sortKey="Audsley, Jennifer" sort="Audsley, Jennifer" uniqKey="Audsley J" first="Jennifer" last="Audsley">Jennifer Audsley</name><name sortKey="Lewin, Sharon R" sort="Lewin, Sharon R" uniqKey="Lewin S" first="Sharon R." last="Lewin">Sharon R. Lewin</name><name sortKey="Lewin, Sharon R" sort="Lewin, Sharon R" uniqKey="Lewin S" first="Sharon R." last="Lewin">Sharon R. 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